He has also made a guest appearance in the BBC Radio 4 series Baldi.
Two of Nighy's most acclaimed stage performances were in National Theatre productions.
At the BAFTA Television Awards in April 2004, he won the Best Actor award for State of Play. In early 2004, The Sunday Times reported that Nighy was on the shortlist for the role of the Ninth Doctor in the 2005 revival of the BBC television series Doctor Who. In 2005, he appeared as Slartibartfast in the film adaptation of The Hitchhiker's Guide to the Galaxy.
He also appeared in the one-off BBC One comedy-drama The Girl in the Café.
Nighy also appeared as General Friedrich Olbricht, one of the principal conspirators, in the 2008 film Valkyrie.