He has the Fox feature "The Other Woman" starring opposite Cameron Diaz and directed by Nick Cassavetes. Since 2012, he has portrayed Lieutenant Kelly Severide in Chicago Fire, Chicago P.
Accola has guest appeared in a number of television series such as How I Met Your Mother, Supernatural and Drop Dead Diva.
In July 2009 Accola starred in the Independent Horror film Deadgirl, which centers on two high school boys who discover an immortal woman in an abandoned asylum.
Candice and other individuals (including TVD’s Kayla Ewell and Kat Graham) are participating in the fight to raise awareness regarding Lyme Disease, a disease that many people suffer from but many more are uneducated about.
On October 18, 2014, Candice and Joe got married in New Orleans.
She also became a stepmother to her new husband Joe King's two daughters.